Foci Photo for Mission SectionScientifically, our laboratory is primarily focused on the development of novel anti-cancer therapeutics for a wide range of solid tumors. In particular, we are interested in creating the next generation of tumor-specific radio-sensitizers, which target key cancer-associated gene mutations. In addition, we are interested in the mechanism of DNA double-strand break (DSB) repair competition in mammalian cells. A common thread among our studies is the use of novel, cell-based screening tools, developed in our laboratory and also by our collaborators.

Shown here is an ultra-high resolution photo of a single cancer cell nucleus, approximately one hour after being exposed to ionizing radiation. This cell has been stained for DNA with DAPI (in blue), and with antibodies specific for two DSB repair proteins, DNA-PK (red) and BRCA1 (green). Each ìspotî represents thousands of these DSB repair proteins clustered around a single DSB.

From a translational perspective, we seek to rapidly advanced our discoveries to the clinic. We are well poised to do this because D. Bindra is a practicing radiation oncologist at the Yale School of Medicine, with access to patients and experience in clinical trials.

Academically, our laboratory is focused on developing the scientific and/or medical careers of undergraduates, medical and graduate students, as well as post-doctoral researchers and fellows. A firm understanding of molecular biology techniques, strategy and tactics are essential for success in science. We try to impart these skills in our staff, during the course of training in the Bindra Laboratory.