People

Ranjit S. Bindra, M.D., Ph.D.

Favorite Gene: DNA-PKcs
Favorite Restaurant in New Haven: Bentara
Favorite Movie / Show: The Wire
Ranjini Sundaram, Ph.D.

Favorite Gene: APP
Favorite Restaurant in New Haven: Istanbul Cafe
Favorite Movie / Show: Jungle Book
Juan Vasquez, M.D.

Favorite Gene: Hackman
Favorite Restaurant in New Haven: Zinc
Favorite Movie / Show: The Sopranos
Bio

I am a faculty member in the Yale Section of Pediatric Hematology/Oncology interested in developing immunotherapies for pediatric tumors. My research is focused on (1) characterizing the impact of oncometabolite-induced homologous recombination defects on the anti-tumor immune response and (2) exploiting oncometabolite-induced homologous recombination defects with different DNA damaging agents to make tumors more sensitive to immunotherapies.

Amrita Sule, Ph.D.

Favorite Gene: ATM Kinase
Favorite Restaurant in New Haven: Food trucks on Cedar St.
Favorite Movie / Show: A Few Good Men
Bio

My research aims to understand oncometabolite-induced DNA repair defects in solid tumors. Our goal is to identify the molecular determinants of synthetic lethal interactions between DNA repair inhibitors and oncometabolites in vitro and in vivo. My other project focuses on developing new class of nanoparticle DNA repair inhibitors to treat glioma and other CNS cancers in collaboration with Mark Saltzman’s lab at Yale.

Ranjith Menon Muraleedharan, Ph.D.

Favorite Gene: H3F3A & AMPK
Favorite Restaurant in New Haven: Parvathy’s Kitchen ( YOU TOLD ME TO BE CREATIVE)
Favorite Movie / Show: Secondhand Lions
Bio

Diffuse intrinsic pontine glioma (DIPG) is a devastating childhood cancer with very limited treatment options. Currently, radiation therapy (RT) alone is the standard of care for DIPG, as no effective chemotherapy regimens exist, and surgery is not feasible because of its location in the brainstem. Recent studies of DIPG have revealed that many of these tumors harbor activating mutations in key genes, such as histone H3 and PPM1D . I will be performing a CRISPR/cas-based gene targeting screen to identify synthetic lethal interactions between H3F3A K27M mutations, as well as PPM1D mutations. Finally, I seek to define the specific bioenergetic and metabolic pathways that are associated with the reprogramming of normal brainstem cells into DIPG.

Susan Gueble, M.D., Ph.D.

Favorite Gene: FANCD2
Favorite Restaurant in New Haven: Mamoun's Falafel
Favorite Movie / Show: Lost
Bio

I am a Yale radiation oncology resident interested in developing therapeutic strategies targeting DNA repair deficiencies within cancers.  My research currently focuses on understanding the biological mechanism of action of novel alkylating compounds for the treatment of temozolomide-resistant gliomas.  I am studying the DNA damage and repair pathways engaged by these compounds and characterizing their effects in different genetic contexts and in combination with DNA repair inhibitors.

Teresa Lee, Ph.D.

Favorite Gene: p53
Favorite Restaurant in New Haven: Chez Moi
Favorite Movie / Show: Twilight Zone
Bio

I work on the development of nanoparticle-encapsulated DNA repair inhibitors as glioblastoma
chemosensitizers. Resistance to the chemotherapeutic TMZ may be mediated by the downstream DNA repair proteins MGMT and PARP. My research aims to sensitize glioblastoma tumors to TMZ using nanoparticle encapsulation combined with a method of direct brain delivery to achieve effective MGMT and PARP inhibition in rat glioblastoma models.

Collin Heer, Ph.D.

Favorite Gene: NAMPT
Favorite Restaurant in New Haven: September in Bangkok
Favorite Movie / Show: 28 Days Later
Bio

My project focuses on selectively enhancing NAD+ consumption or inhibiting NAD+ production to exploit NAD metabolic vulnerabilities in cancer cells.

Jennifer Garbarino, Ph.D.

Favorite Gene: ATRX
Favorite Restaurant in New Haven: August
Favorite Movie / Show: Star Trek
Bio

Alpha Thalassemia/Mental Retardation Syndrome X-Linked (ATRX) is mutated frequently in gliomas and is thought to be an important target for potential therapeutics. My research focuses on characterizing DNA repair defects induced by ATRX loss and whether they confer sensitivity to DNA repair inhibitors. I am also identifying these deficiencies in the context of IDH1/2 mutation, as ATRX and IDH1 mutations often cooccur in tumors.

Sachita Ganesa

Favorite Gene: MSH2
Favorite Restaurant in New Haven: Sherkaan
Favorite Movie / Show: Zumbo's Just Desserts
Bio

My research looks at the intricacies of ATR activation by the DNA mismatch repair pathway, as it relates to MGMT-status upon treatment with temozolomide.

Kingson Lin

Favorite Gene: MGMT
Favorite Restaurant in New Haven: L'Orcio
Favorite Movie / Show: How I Met Your Mother
Bio

My research aims to characterize how clinically used DNA alkylators damage DNA on the molecular level using chemical analytical techniques such as LCMS and NMR. Furthermore, I am interested in the DNA damage response (DDR) pathways responsible for repair of specific types of damage with the goal of developing novel alkylating agents that preferential target cancers with intrinsically deficient DDR pathways.

Matt Murray

Favorite Gene: DNMT2
Favorite Restaurant in New Haven: Bonchon
Favorite Movie / Show: The Perks of Being a Wallflower
Bio

My research focuses on the novel epigenetic role of
PPM1D. We previously identified mutant or genetically amplified PPM1D (a phosphatase that regulates cell cycle proteins and p53/p38 signaling) causes a CpG Island Hypermethylation Phenotype (CIMP)-like phenotype which results in the silencing of many genes. The goal of my work is to understand the mechanisms in which PPM1D imposes these epigenetic changes and how we can use this knowledge to drive the development of novel therapeutics.

Katelyn Noronha

Favorite Gene: POLQ
Favorite Restaurant in New Haven: Miya's Sushi
Favorite Movie / Show: Chef's Table
Bio

My research aims to determine how oncometabolites affect
nonhomologous end joining and alternative end joining pathways. Our goal is to use this information to identify and evaluate molecular targets for the treatment of tumors that produce oncometabolites due to mutations in TCA cycle enzymes.

Sateja Paradkar

Favorite Gene: PARG
Favorite Restaurant in New Haven: Anaya Sushi and Ramen
Favorite Movie / Show: The Newsroom Season 1
Bio

My research aims to understand the mechanism underlying the synthetic lethal interaction between mutations in a metabolic gene, IDH1/2, and DNA repair inhibitors and DNA damaging agents. This will support the development of novel therapeutic strategies and drug combinations for IDH1/2-mutant cancers such as glioblastomas.

Jinny Van Doorn

Favorite Gene: APOBEC
Favorite Restaurant in New Haven: T-swirl Crepe
Favorite Movie / Show: Spirited Away
Bio

After graduating from Yale in 2019 with a degree in Biochemistry, I have continued to work in the Bindra lab as a post-bac while applying to graduate school. My research has encompassed characterizing in vitro and in vivo the efficacy of drug delivery systems* and different therapeutic combinations** for cancer treatment.

*pH-targeted and nanoparticle-mediated drug delivery systems

**i.e. synthetic lethal interactions between tumor mutations, oncometabolites, and DNA repair inhibitors, as well as synergistic interactions between DNA repair inhibitors and conventional therapies

Joseph Edmonds

Favorite Gene: POLB
Favorite Restaurant in New Haven: Looking for recommendations
Favorite Movie / Show: The Scooby-Doo Movie
Bio

I’m picking up on a project where we are attempting to determine potential Nampt inhibitors to ultimately treat cancer. We are now moving into the cell culture trial aspect of the project.

Rytis Sidabras

Favorite Gene: MAP3K3
Favorite Movie / Show: It's Always Sunny in Philadelphia
Bio

I am a research associate with an industry background. My goal is to become proficient in an academic laboratory setting so that I may work on various projects and help achieve the goals of the Bindra lab.

Amrit Dhawan

Favorite Restaurant in New Haven: Geronimo’s
Favorite Movie / Show: Shrimad Bhagwad Gita
Bettina Harris

Favorite Gene: All Bindra Lab Genes
Favorite Restaurant in New Haven: Lenny & Joe's
Favorite Movie / Show: The Book of Eli

Alumni

Ahmed Salem, Ph.D.
Aravind Nambiar Kalathil
Bert Geng
Chris Corso M.D., Ph.D.
Christopher Hong, M.D.
Christopher Jackson, M.D.
Greg Breuer, M.D,. Ph.D.
Jaime Ko
Jason Beckta, M.D., Ph.D.
Jillian Eckroate
Jiayu Liang, M.D.
John Soong, Ph.D.
Jonathan Bezney
Karen Purshouse, M.D.
Karo Takasaki, M.D.
Kriteeka Dahal
Monica Niger, M.D.
Nalin Leelatian, M.D., Ph.D.
Namrata Chandok, M.D.
Nathan Fons, Ph.D.
Nate Robinson, M.D.
Ryan Hannon
Ryan McLean
Sarah Gao
Seth Noorbakhsh
Savina Kim
Vikram Jairam, M.D.
William Sullivan
Yuhang Jiang, Ph.D.

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