Publications

Selected publications below. For a more extensive and updated list, click here.

  
Garbarino J, Eckroate J, Sundaram RK, Jensen RB, Bindra RS. Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity. Transl Oncol. 2021 Jun 9;14(9):101147. doi: 10.1016/j.tranon.2021.101147. PMID: 34118569.   [PubMed] 
Sule A, Van Doorn J, Sundaram RK, Ganesa S, Vasquez JC, Bindra RS. Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors. NAR Cancer. 2021 May 17;3(2):zcab018. doi: 10.1093/narcan/zcab018. PMID: 34027408.   [PubMed] 
Paradkar S, Herrington J, Hendricson A, Hewawasam P, Plummer M, Hoyer D, Sundaram RK, Surovtseva YV, Bindra RS. Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore. Oncotarget. 2021 Apr 27;12(9):891-906. doi: 10.18632/oncotarget.27933. PMID: 33953843.   [PubMed] 
Sulkowski PL, Oeck S, Dow J, Economos NG, Mirfakhraie L, Liu Y, Noronha K, Bao X, Li J, Shuch BM, King MC, Bindra RS, Glazer PM. Oncometabolites suppress DNA repair by disrupting local chromatin signalling. Nature. 2020 Jun;582(7813):586-591. doi: 10.1038/s41586-020-2363-0. Epub 2020 Jun 3. PMID: 32494005.   [PubMed] 
Fons NR, Sundaram RK, Breuer GA, Peng S, McLean RL, Kalathil AN, Schmidt MS, Carvalho DM, Mackay A, Jones C, Carcaboso ÁM, Nazarian J, Berens ME, Brenner C, Bindra RS. PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nat Commun. 2019 Aug 22;10(1):3790. doi: 10.1038/s41467-019-11732-6. PMID: 31439867.   [PubMed] 
Jackson CB, Noorbakhsh SI, Sundaram RK, Kalathil AN, Ganesa S, Jia L, Breslin H, Burgenske DM, Gilad O, Sarkaria JN, Bindra RS. Temozolomide Sensitizes MGMT-Deficient Tumor Cells to ATR Inhibitors. Cancer Res. 2019 Sep 1;79(17):4331-4338. doi: 10.1158/0008-5472.CAN-18-3394. Epub 2019 Jul 4. PMID: 31273061.   [PubMed] 
Sulkowski PL, Sundaram RK, Oeck S, Corso CD, Liu Y, Noorbakhsh S, Niger M, Boeke M, Ueno D, Kalathil AN, Bao X, Li J, Shuch B, Bindra RS, Glazer PM. Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair. Nat Genet. 2018 Aug;50(8):1086-1092. doi: 10.1038/s41588-018-0170-4. Epub 2018 Jul 16. PMID: 30013182.   [PubMed] 
Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. Sci Transl Med. 2017 Feb. PMID: 28148839.   [PubMed] 
Shahbazian D, Bindra RS, Kluger HM, Glazer PM. Radiation sensitivity and sensitization in melanoma. Pigment Cell Melanoma Res. 2013 Nov;26(6):928-30. doi: 10.1111/pcmr.12147. Epub 2013 Aug 12. PubMed PMID: 23870422.   [PubMed] 
Bindra RS, Goglia AG, Jasin M, Powell SN. Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells. Nucleic Acids Res. 2013 Jun;41(11):e115. doi: 10.1093/nar/gkt255. Epub 2013 Apr 12. PubMed PMID: 23585275; PubMed Central PMCID: PMC3675474.   [PubMed] 
Bindra RS, Yahalom J. The important role of radiation therapy in early-stage diffuse large B-cell lymphoma: time to review the evidence once again. Expert Rev Anticancer Ther. 2011 Sep;11(9):1367-78. doi: 10.1586/era.11.88. Review. PubMed PMID: 21929311.   [PubMed] 
Hegan DC, Lu Y, Stachelek GC, Crosby ME, Bindra RS, Glazer PM. Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2201-6. doi: 10.1073/pnas.0904783107. Epub 2010 Jan 19. PubMed PMID: 20133863; PubMed Central PMCID: PMC2836641.   [PubMed] 
Powell SN, Bindra RS. Targeting the DNA damage response for cancer therapy. DNA Repair (Amst). 2009 Sep 2;8(9):1153-65. doi: 10.1016/j.dnarep.2009.04.011. Epub 2009 Jun 5. Review. PubMed PMID: 19501553.   [PubMed] 
Glazer PM, Bindra RS. Introduction: the evolving picture of the hypoxic tumour microenvironment. Curr Mol Med. 2009 May;9(4):399-400. PubMed PMID: 19519396.   [PubMed] 
Bindra RS, Glazer PM. Co-repression of mismatch repair gene expression by hypoxia in cancer cells: role of the Myc/Max network. Cancer Lett. 2007 Jul 8;252(1):93-103. Epub 2007 Feb 1. PubMed PMID: 17275176.   [PubMed] 
Bindra RS, Crosby ME, Glazer PM. Regulation of DNA repair in hypoxic cancer cells. Cancer Metastasis Rev. 2007 Jun;26(2):249-60. Review. PubMed PMID: 17415527.   [PubMed] 
Bindra RS, Glazer PM. Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia. Oncogene. 2007 Mar 29;26(14):2048-57. Epub 2006 Sep 25. PubMed PMID: 17001309.   [PubMed] 
Huang LE, Bindra RS, Glazer PM, Harris AL. Hypoxia-induced genetic instability–a calculated mechanism underlying tumor progression. J Mol Med (Berl). 2007 Feb;85(2):139-48. Epub 2006 Dec 20. Review. PubMed PMID: 17180667.   [PubMed] 
Gibson SL, Bindra RS, Glazer PM. CHK2-dependent phosphorylation of BRCA1 in hypoxia. Radiat Res. 2006 Oct;166(4):646-51. PubMed PMID: 17007555.   [PubMed] 
Bindra RS, Glazer PM. Basal repression of BRCA1 by multiple E2Fs and pocket proteins at adjacent E2F sites. Cancer Biol Ther. 2006 Oct;5(10):1400-7. Epub 2006 Oct 30. PubMed PMID: 17106239.   [PubMed] 
Gibson SL, Bindra RS, Glazer PM. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Res. 2005 Dec 1;65(23):10734-41. PubMed PMID: 16322218.   [PubMed] 
Bindra RS, Gibson SL, Meng A, Westermark U, Jasin M, Pierce AJ, Bristow RG, Classon MK, Glazer PM. Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. Cancer Res. 2005 Dec 15;65(24):11597-604. PubMed PMID: 16357170.   [PubMed] 
Bindra RS, Schaffer PJ, Meng A, Woo J, Måseide K, Roth ME, Lizardi P, Hedley DW, Bristow RG, Glazer PM. Alterations in DNA repair gene expression under hypoxia: elucidating the mechanisms of hypoxia-induced genetic instability. Ann N Y Acad Sci. 2005 Nov;1059:184-95. PubMed PMID: 16382054.   [PubMed] 
Meng AX, Jalali F, Cuddihy A, Chan N, Bindra RS, Glazer PM, Bristow RG. Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells. Radiother Oncol. 2005 Aug;76(2):168-76. PubMed PMID: 16026872.   [PubMed] 
Bindra RS, Glazer PM. Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesis. Mutat Res. 2005 Jan 6;569(1-2):75-85. Review. PubMed PMID: 15603753.   [PubMed] 
Bindra RS, Schaffer PJ, Meng A, Woo J, Måseide K, Roth ME, Lizardi P, Hedley DW, Bristow RG, Glazer PM. Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. Mol Cell Biol. 2004 Oct;24(19):8504-18. PubMed PMID: 15367671; PubMed Central PMCID: PMC516750.   [PubMed] 
Mihaylova VT, Bindra RS, Yuan J, Campisi D, Narayanan L, Jensen R, Giordano F, Johnson RS, Rockwell S, Glazer PM. Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Mol Cell Biol. 2003 May;23(9):3265-73. PubMed PMID: 12697826; PubMed Central PMCID: PMC153206.   [PubMed] 
Bindra RS, Vasselli JR, Stearman R, Linehan WM, Klausner RD. VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells. Cancer Res. 2002 Jun 1;62(11):3014-9. PubMed PMID: 12036906.   [PubMed] 
Simon DB, Bindra RS, Mansfield TA, Nelson-Williams C, Mendonca E, Stone R, Schurman S, Nayir A, Alpay H, Bakkaloglu A, Rodriguez-Soriano J, Morales JM, Sanjad SA, Taylor CM, Pilz D, Brem A, Trachtman H, Griswold W, Richard GA, John E, Lifton RP. Mutations in the chloride channel gene, CLCNKB, cause Bartter’s syndrome type III. Nat Genet. 1997 Oct;17(2):171-8. PubMed PMID: 9326936.   [PubMed] 
Kochar MS, Bindra RS. The additive effects of smoking and hypertension. More reasons to help your patients kick the habit. Postgrad Med. 1996 Nov;100(5):147-8, 151-4, 159-60. Review. PubMed PMID: 8917330.   [PubMed] 
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